By: Emily Caldwell
Published on November 16, 2014
WASHINGTON, D.C. Two or more serious hits to the head within days of each other can interfere with the brains ability to use sugar its primary energy source to repair cells damaged by the injuries, new research suggests.
The brains ability to use energy is critical after an injury. In animal studies, Ohio State University scientists have shown that brain cells ramp up their energy use six days after a concussion to recover from the damage. If a second injury occurs before that surge of energy use starts, the brain loses its best chance to recover.
In mice, the lack of energy use for recovery led to inflammation, degeneration of brain cell segments and problems with learning and memory.Zachary Weil
In new work presented Sunday (11/16) at Neuroscience 2014, the annual meeting of the Society for Neuroscience, these same scientists have observed that even if the required glucose is present in the brain, faulty insulin signals in an injured brain dont allow cells to take up the sugar and use it.
All clinical signs suggest that two head injuries close together are dangerous and can even be deadly. But the science behind whats actually going on in the brain is still unclear and knowing these details could help in deciding when to return athletes to play or military members to service, said lead author Zachary Weil, assistant professor of neuroscience at Ohio State.
Lots of data show that if two head injuries occur close together, its not like 1 plus 1. Its more like 1 plus 10, Weil said. So our goals are to understand what it is about injuries close together that makes us more vulnerable, and can we eventually use some sort of biological signal to tell when its safe to go back?
Weil said the discovery that insulin resistance plays a role in brain recovery after injury could also help explain the development of a brain disease seen in professional athletes who have had multiple traumas to the head chronic traumatic encephalopathy, or CTE. Several CTE symptoms resemble Alzheimers disease memory problems, disorientation and trouble concentrating and the link between defective insulin signals and Alzheimers is already established.
With injury, the damaged cells are not able to use energy even though they need it and the glucose is there. It appears thats because the signals are messed up, he said. Its the same thing seen in Alzheimers patients. Cells are chronically undernourished even though the sugar level might be high.
In earlier animal studies, Weil and colleagues compared the effects of head injuries that occurred either three days or 20 days apart. Of all the animals, the mice injured three days apart had higher inflammation in the brain, more degeneration of axons the long, slender extension of the nerve cell body and problems learning how to navigate a maze and remembering the lessons they did manage to learn. Neurons need healthy axons to communicate with each other.
Mice with a single injury or head blows 20 days apart both showed the surge in brain energy use six days after the injury. The brains in mice injured three days apart never developed such a high level of glucose use.
With the second injury, demands for energy might outstrip the ability of the damaged cells to actually use the energy, Weil said.
This research was published in a recent issue of the journal Neurobiology of Disease.
In follow-up work presented at Neuroscience 2014, the researchers examined brain tissue in mice that had experienced no injury, one concussion or two head injuries 24 hours apart. After treating the tissue with insulin, the scientists measured activation levels of a key protein in the insulin signaling process. In mice with no injury, the protein activation was increased by the presence of insulin. But the injured brains did not respond to the presence of insulin at all. Without activation of those signals, brain cells have no way to make use of their glucose energy source.
This means that traumatic brain injury induces insulin resistance in the brain, Weil said. So we need to work on finding ways to acutely increase insulin sensitivity rather than increasing the actual amount of insulin in the brain.
Weil conducted the research with co-authors Kristopher Gaier and Kate Karelina, both of Ohio States Department of Neuroscience.
To reach Weil during Neuroscience 2014, send him an email or call Emily Caldwell at 614-893-4261.
Scientific Presentation: 8:15 to 8:30 a.m. Nov. 16, Washington Convention Center Room 150B, Symposium 113.02, Brain: Cellular and molecular mechanisms